The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 1990
Filed:
Feb. 03, 1988
Applicant:
Inventors:
Michiel E Ultee, Belle Mead, NJ (US);
Vernon L Alvarez, Morrisville, PA (US);
Assignee:
Cytogen Corporation, Princeton, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P / ; G01N / ; C07K / ; A61K / ;
U.S. Cl.
CPC ...
435 681 ; 435188 ; 435272 ; 436512 ; 436547 ; 436548 ; 935107 ; 530388 ; 530389 ; 424-9 ;
Abstract
A novel method for preparing soluble antibody fragment compositions having superior characteristics for targeted delivery when administered in vivo are disclosed. The antibody fragment compositions are characterized by substantially the same immunospecificity as the unconjugated antibody and aqueous solubility such that they are suitable for in vivo administration. Therapeutic and diagnostic methods utilizing the antibody fragment compositions are also disclosed.