The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 1990
Filed:
Jan. 27, 1988
Applicant:
Inventors:
Nandini Katre, El Cerrito, CA (US);
Michael J Knauf, San Bruno, CA (US);
Assignee:
Cetus Corporation, Emeryville, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; A61K / ;
U.S. Cl.
CPC ...
530351 ; 530350 ; 530402 ; 530403 ; 530404 ; 530405 ; 530406 ; 530408 ; 530409 ; 530410 ; 6048901 ; 6048911 ; 514-2 ; 514-8 ; 514 12 ; 514 21 ; 424422 ; 424443 ; 424464 ; 424 851 ; 424 852 ;
Abstract
A pharmaceutical composition is prepared wherein biologically active conjugated interleukin-2 is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated IL-2, which is not water soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to one or more succinyl groups by reaction with succinic anhydride.