The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 1990
Filed:
Sep. 07, 1984
Applicant:
Inventors:
Lawrence I Greenfield, Albany, CA (US);
Donald A Kaplan, Midland, MI (US);
Danute E Nitecki, Berkeley, CA (US);
Assignee:
Cetus Corporation, Emeryville, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ;
U.S. Cl.
CPC ...
530388 ; 530350 ; 530387 ; 530389 ; 530390 ; 530391 ; 530820 ; 530825 ; 424 8591 ; 424 88 ; 424 92 ; 514 21 ; 514-2 ; 435 691 ; 435 697 ;
Abstract
A novel class of polypeptides of the general formula (F-(Pro).sub.n).sub.m F, wherein F represents a flexible amino acid sequence wherein each amino acid is individually selected from the group consisting of serine, glycine, and threonine, and n is an integer from 4-8 inclusive and m is an integer from 1-4 inclusive, is disclosed. Thses polypeptides are useful in the construction of conjugates between antibodies and peptide toxins. The preparation of such conjugate toxins by linking antibodies to toxin/spacer composites prepared by recombinant techniques is also disclosed.