The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 1989
Filed:
May. 21, 1987
Applicant:
Inventors:
John H Crowe, Davis, CA (US);
Lois M Crowe, Davis, CA (US);
Assignee:
The Regents of the University of California, Berkeley, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ;
U.S. Cl.
CPC ...
424 941 ; 424 944 ; 514-2 ; 514-3 ; 514 76 ; 514 77 ; 514 78 ; 514 44 ; 514579 ; 514646 ; 435-4 ; 435 26 ; 436829 ;
Abstract
A method for preserving liposomes includes freeze-drying liposomes most preferably having an average size of about 50 nm to 100 nm with a disaccharide preserving agent being present both internally (with the encapsulated liposomal contents) and externally. The disaccharide component is in a weight ratio with respect to the lipid component of from at least about 0.1:1 to not greater than about 4:1 and is preferably trehalose. When the lyophilizates are reconstituted by rehydration, the resultant liposomes can retain up to 100% of the originally encapsulated contents.