The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 1987
Filed:
Oct. 21, 1985
Applicant:
Inventors:
Alan B Chmurny, Frederick, MD (US);
Akiva T Gross, Rockville, MD (US);
Robert J Kupper, Mount Airy, MD (US);
Rowena L Roberts, Derwood, MD (US);
Assignee:
W. R. Grace & Co., New York, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C12P / ; A61K / ;
U.S. Cl.
CPC ...
560 40 ; 530333 ; 435 70 ;
Abstract
Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspertame or derivative by enzymatic coupling of phenylserine or derivative with aspertic acid or derivative. Hydrogenation of the coupled product to give as final product aspertame or analog with related processes and products.