The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 1987
Filed:
May. 02, 1985
Applicant:
Inventors:
David F Mark, Danville, CA (US);
Alice M Wang, Walnut Creek, CA (US);
Martha B Ladner, Richmond, CA (US);
Abla A Creasey, Piedmont, CA (US);
Janelle N Van Arsdell, Richmond, CA (US);
Leo S Lin, Fremont, CA (US);
Assignee:
Cetus Corporation, Emeryville, CA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P / ; C12N / ; C12N / ; A61K / ;
U.S. Cl.
CPC ...
435 68 ; 4351723 ; 435253 ; 435317 ; 514-8 ; 514 12 ; 530350 ; 530351 ; 530395 ; 530808 ; 424 85 ; 424 88 ; 536 27 ;
Abstract
Human Tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.