The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 1986
Filed:
Oct. 09, 1984
Fujio Nakagame, Tokyo, JP;
Haruo Honda, Kawasaki, JP;
Teppei Maruyama, Komae, JP;
Noriko Saito, Kawasaki, JP;
Tomoaki Kimoto, Matsudo, JP;
Terumo Kabushiki Kaisha, Tokyo, JP;
Abstract
A pharmaceutical composition containing urokinase and a physiological absorption enhancer comprising higher fatty acids, a polyalkylene glycol and calcium is disclosed. Whereas urokinase which is decomposed and inactivated in the stomach and is poorly absorbed from the intestinal tract cannot be orally administered, it can be orally administered in the form of the present composition by applying an enteric coating, because urokinase in the composition is highly absorbable from the intestinal tract. It is desirable in the present composition in view of the stability and sustained absorbability that urokinase is contained in said composition in the form of a liposome preparation in which the urokinase is incorporated in voids of the liposome. The components are incorporated in the present composition at a ratio of 0.01-2 mg. of the higher fatty acid, 0.01-5 mg. of the polyalkylene glycol and 0.0001-0.1 mg. of the calcium per 100 units of urokinase. The present composition is satisfactory for use as a thrombolytic agent.