The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 1983
Filed:
Nov. 05, 1979
Avram Goldstein, Stanford, CA (US);
Addiction Research Foundation, Palo Alto, CA (US);
Abstract
Novel opioid compounds are provided having a phenolic hydroxyl and a pentet of alternating basic hydrophilic and hydrophobic groups derived from basic amino acids and hydrophobic amino acids. Desirably, the pentet, usually sextet, is separated from the phenolic ring by at least about 3 atoms in a chain, preferably at least about 15 atoms in a chain and not more than about 30 atoms in a chain (for rings one will take the average of the shortest and longest distances). Particularly, a polypeptide is provided having tyrosyl at the amine end, desirably as the first amino acid of leu- or met-enkephalin and a sextet of alternating basic hydrophilic and hydrophobic amino acids spaced from the enkephalin by at least about one amino acid. Desirably, the polypeptide is at least 1,200 molecular weight and under about 2,500 molecular weight.