The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 13, 1981

Filed:

Nov. 28, 1977
Applicant:
Inventors:

Leonid E Kholodov, Moscow, SU;

Vladimir G Yashunsky, Moscow, SU;

Roald A Altshuler, Moscow, SU;

Mikhail D Mashkovsky, Moscow, SU;

Valentina V Ogorodnikova, Moscow, SU;

Zoya A Olovyanishnikova, Moscow, SU;

Anna S Vitvitskaya, Leningrad, SU;

Valery A Parshin, Moscow, SU;

Ekaterina A Kelekhsaeva, Moscow, SU;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
548125 ; 424272 ;
Abstract

N-acyl sydnonimines of the formula: ##STR1## wherein R is phenyl, .beta.-phenylethyl, dl-.alpha.-methyl-.beta.-phenylethyl or l-.alpha.-methyl-.beta.-phenylethyl; R' is hydrogen, phenyl; X is a lower alkyl, phenyl, ##STR2## wherein R' is hydrogen, a halogen, a lower fluorinated alkyl; R'' is hydrogen, a halogen, a lower alkyl; when R is dl-.alpha.-methyl-.beta.-phenylethyl, R' is H, R' is Cl, R'' is only Cl, while when R' is H, X is NHC.sub.6 H.sub.5 R is only l-.alpha.-methyl-.beta.-phenylethyl; when X is phenyl, R and R' are each phenyl only. The method for preparing sydnonimine N-acylderivatives comprises reacting N-nitrosoderivatives of N-substituted nitriles of .alpha.-aminoacids of the formula: ##STR3## wherein R is phenyl, .beta.-phenylethyl, di-.alpha.-methyl-.beta.-phenylethyl or l-.alpha.-methyl-.beta.-phenylethyl; R' is H, phenyl; when R' is phenyl R is phenyl only, with an acylation agent in a solvent medium in the presence of a basic-character catalyst, followed by isolation of the desired product.


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