The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 1979
Filed:
Oct. 25, 1977
Endre A Balazs, Riverdale, NY (US);
Biotrics, Inc., Riverdale, NY (US);
Abstract
An ultra-pure, high molecular weight hyaluronic acid fraction which is characterized by the absence of significant cellular infiltration of the vitreous and anterior chamber, absence of significant flare in the aqueous humor, absence of significant haze or flare in the vitreous and absence of pathological changes to the cornea, lens, iris, retina, and choroid of the owl monkey eye when one milliliter of a 1% solution of the sodium salt thereof dissolved in physiological buffer is implanted in the vitreous replacing about one-half the existing liquid vitreous. This material is obtained from animal tissue containing hyaluronic acid by a process which comprises removing the blood from animal tissue containing hyaluronic acid, extracting hyaluronic acid therefrom, deproteinizing the hyaluronic acid extract, and removing any unidentified inflammation causing agents persent therein by treating the deproteinized hyaluronic acid extract at a pH of 6.0 - 7.0 with a volume of chloroform at least about equal to that of the deproteinized extract, to form a two-phase mixture which is then stirred, sufficiently to ensure intimate contact between said two phases, at about 15.degree. - 40.degree. C., followed by separating out and discarding the chloroform phase.