The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 1979
Filed:
Aug. 13, 1976
Allen B Clarkson, Jr, New York, NY (US);
Fredrick H Brohn, New York, NY (US);
The Rockefeller University, New York, NY (US);
Abstract
A composition comprising from 0.02 to 17 parts by weight of glycerol per part by weight of an iron chelating agent selected from the group consisting of salicyl hydroxyamic acid; 2,3- and 3,4-dihydroxy benzoic acid; and halobenzohydroxamic; e.g., m-iodobenzohydroxamic acid and m-chlorobenzohydroxamic acid; as well as their C.sub.1 to C.sub.4 alkyl esters. When this composition is administered parenterally, it is found to block aerobic and anaerobic glucose catabolism and thereby accomplish control of several trypanosomes, including Trypanosoma brucei, T. gambiensi, T. rhodesiensi, T. equiperdum, T. evansi, T. congolense and T. vivax. In mammals, the therapeutic dosage is calculated to provide at least 138 mg/kg of body weight of glycerol and at least 96 mg/kg of body weight of the iron chelating agent.