The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2026
Filed:
Jul. 21, 2021
The Scripps Research Institute, La Jolla, CA (US);
James C. Paulson, Del Mar, CA (US);
Landon J. Edgar, San Diego, CA (US);
Andrew J. Thompson, San Diego, CA (US);
Chika Kikuchi, San Diego, CA (US);
Brett Garabedian, Del Mar, CA (US);
Xiaoshuang Wang, San Diego, CA (US);
Eleanor Bashian, Laguna Niguel, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
The present invention provides methods for enhancing T cell activation and expansion, and methods for stimulating a T cell immune response in a subject. The methods of the invention involve the use of a targeting agent-enzyme conjugate that contains (a) a targeting moiety that specifically binds a cell surface molecule on T cells, and (b) a sialidase or enzymatically active fragment thereof. Also provided in the invention are targeting agent-enzyme conjugates that can be used in the therapeutic methods, including antibody conjugates that are formed of a sialidase and a T cell targeting antibody (e.g., an anti-PD1 antibody).