Electroporation/electrochemotherapy of surgically sensitive regions

Abstract

Disclosed herein are devices for in-vivo electroporation of target cells in sensitive and/or difficult-to-access regions of a living body and systems and methods utilizing thereof. The devices include non-invasive structured electrodes placed at a target region or in the vicinity of the target region without causing bleeding, tearing, or any injuries. The target cells are electroporated by applying at least one sequence of electric voltage pulses between the non-invasive structured utilizing an electrical pulse generator. An electroporation process may be assisted by tracking and adjusting a location of one or more electrodes of the devices utilizing a camera attached to the one or more electrodes placed inside the target region. An electroporation process may be assisted by tightening a contact between one or more electrodes of the devices and the target region by pulling the target region towards the one or more electrodes utilizing a vacuum pressure generator.