The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2026
Filed:
Mar. 30, 2021
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Michal Achmatowicz, San Diego, CA (US);
Sheng Cui, Lexington, MA (US);
Tsang-Lin Hwang, Camarillo, CA (US);
Neil Fred Langille, Sudbury, MA (US);
Janine K. Tom, Thousand Oaks, CA (US);
James E. Huckle, Moorpark, CA (US);
Markian Stec, Moorpark, CA (US);
Tian Wu, Newbury Park, CA (US);
Sean P. Brown, Half Moon Bay, CA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01); A61K 31/553 (2006.01); A61P 35/00 (2006.01); C07D 513/06 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); C07B 2200/13 (2013.01);
Abstract
Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).