The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2026
Filed:
Apr. 08, 2022
Paolo L. Manfredi, Miami Beach, FL (US);
Charles E. Inturrisi, New York, NY (US);
Paolo L. Manfredi, Miami Beach, FL (US);
Charles E. Inturrisi, New York, NY (US);
Andrea Mattarei, Perarolo di Vigonza, IT;
Marco Banzato, Galzignano Terme, IT;
Alberto Furlan, Padua, IT;
Alberto Ongaro, Campolongo Maggiore, IT;
Brian H. Heasley, Wake Forest, NC (US);
Zachary D. Tucker, Cary, NC (US);
Other;
Abstract
Methods for the synthesis of enantiopure (S)-methadone, (R)-methadone, (R,S)-methadone and related analogues starting from optically active or racemic N-substituted cyclic sulfamidates, or N-substituted aziridines with retention of stereochemical configuration. The methods avoid the formation of isomethadone-nitrile by-products observed under the previously reported conditions, namely the ring-opening reaction of the corresponding 1,1,2-trimethylaziridin-1-ium salt and the 2,2-diphenylacetonitrile anion, resulting in improved yields and facile purification operations.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile