The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 28, 2026

Filed:

Dec. 23, 2020
Applicant:

Medicis Pharmaceutical Corporation, Bridgewater, NJ (US);

Inventors:

Andrew R. Miksztal, Palo Alto, CA (US);

Shawn Johnstone, Saint-Lazare, CA;

Michael Holtz-Mulholland, Lachine, CA;

Flavio Lopez, Florence, SC (US);

Howard Sard, Arlington, MA (US);

Jie Li, Winchester, MA (US);

Mario Gonzalez, Winchester, MA (US);

Stephan D. Parent, West Lafayette, IN (US);

Travis Lee Houston, Lafayette, IN (US);

Robert Wenslow, Cranbury, NJ (US);

Assignee:

Medicis Pharmaceutical Corporation, Bridgewater, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07J 31/00 (2006.01); A61K 31/56 (2006.01); A61P 1/16 (2006.01); A61P 3/00 (2006.01); A61P 3/06 (2006.01);
U.S. Cl.
CPC ...
C07J 31/006 (2013.01); C07B 2200/13 (2013.01);
Abstract

Crystalline and liquid crystalline forms of 25HC3S sodium are described herein. The disclosure includes Forms I, II, III, V, IX, XI, and XIII of 25HC3S sodium and combinations thereof. Pharmaceutical formulations of said forms, or combinations thereof, and methods of treating or preventing disease such as hypercholesterolemia, hypertriglyceridemia, and conditions related to fat accumulation and inflammation (e.g., non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, and atherosclerosis) are further disclosed herein. Methods for preparing 25HC3S are also provided.


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