logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12680080 B1

PDFFull Text
Date of Patent:
Jul. 14, 2026

Filed:

Jun. 10, 2022

Proliferative liver organoid, metabolically activated liver organoid, and use thereof

Applicants:

Jsr Corporation, Tokyo, JP;

Keio University, Tokyo, JP;

Inventors:

Norio Masuda, Tokyo, JP;

Toshiro Sato, Tokyo, JP;

Ryo Igarashi, Tokyo, JP;

Assignees:

JSR Corporation, Tokyo, JP;

KEIO UNIVERSITY, Tokyo, JP;

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P.

Primary Examiner:

Titilayo Moloye

Assistant Examiner:

Risa undefined Takenaka

Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/0735 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0672 (2013.01); C12N 5/0606 (2013.01); C12N 5/0671 (2013.01); C12N 5/0677 (2013.01); C12N 5/0679 (2013.01); C12N 2501/115 (2013.01); C12N 2501/117 (2013.01); C12N 2501/12 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/39 (2013.01); C12N 2501/999 (2013.01); C12N 2503/04 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01); C12N 2511/00 (2013.01); C12N 2513/00 (2013.01); C12N 2533/90 (2013.01);
Abstract

A production method for a proliferative liver organoid includes culturing liver stem cells or a tissue fragment including liver stem cells in a growth medium to obtain a proliferative liver organoid, in which the growth medium contains an interleukin-6 family cytokine. A production method for a metabolically activated liver organoid includes culturing the proliferative liver organoid produced by the production method for a proliferative liver organoid in a differentiation medium to obtain a metabolically activated liver organoid, in which the differentiation medium does not substantially contain an interleukin-6 family cytokine.

Find Patent Forward Citations

Masuda, Norio. (2026). Proliferative liver organoid, metabolically activated liver organoid, and use thereof (U.S. Patent No. 12680080). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12680080

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…