The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 09, 2026

Filed:

Mar. 19, 2019
Applicant:

Algipharma As, Sandvika, NO;

Inventors:

Aristides Tagalakis, Liverpool, GB;

Stephen Hart, London, GB;

Are Kristiansen, Vøyenenga, NO;

Arne Dessen, Røyken, NO;

Philip D. Rye, Eiksmarka, NO;

Assignee:

AlgiPharma AS, Sandvika, NO;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); A61K 47/61 (2017.01); C12N 15/113 (2010.01); A61K 45/06 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 47/6929 (2017.08); A61K 47/61 (2017.08); C12N 15/1131 (2013.01); A61K 45/06 (2013.01); B82Y 5/00 (2013.01); C12N 2750/14123 (2013.01); C12N 2750/14143 (2013.01);
Abstract

A method for translocating a cationic micro/nanoparticle across a mucus layer, the method including (a) contacting the mucus layer with at least one alginate oligomer, the alginate oligomer having at least 70% mannuronate residues, together with the cationic micro/nanoparticle; or (b)(i) contacting the cationic micro/nanoparticle with an alginate oligomer having at least 70% mannuronate residues thereby forming a micro/nanoparticle carrying the alginate oligomer, and (b)(ii) contacting the mucus layer with the micro/nanoparticle prepared in step (b)(i). There is also provided a method for translocating a molecule of interest across a mucus layer including contacting the mucus layer with a micro/nanoparticle which is formed of self-assembling micro/nanoparticle forming components, wherein at least one is a cationic micro/nanoparticle forming agent and at least one is an alginate oligomer which has at least 70% mannuronate residues, and further comprises the molecule of interest, optionally wherein the molecule of interest is covalently bound to one or more of the self-assembling micro/nanoparticle forming components.


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