The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2026
Filed:
Sep. 17, 2019
Applicant:
Universiteit Gent, Ghent, BE;
Inventors:
Stefaan De Smedt, Mariakerke, BE;
Rein Verbeke, Bruges, BE;
Heleen Dewitte, Gentbrugge, BE;
Ine Lentacker, Ledeberg, BE;
Assignee:
UNIVERSITEIT GENT, Ghent, BE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/69 (2017.01); A61K 31/7105 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 47/6935 (2017.08); A61K 31/7105 (2013.01); A61K 39/00 (2013.01); A61K 39/0011 (2013.01); A61K 45/06 (2013.01); A61K 47/543 (2017.08); A61K 47/549 (2017.08); A61K 48/0025 (2013.01); A61P 35/00 (2018.01); A61K 2039/5154 (2013.01); A61K 2039/53 (2013.01); A61K 2039/585 (2013.01); B82Y 5/00 (2013.01);
Abstract
The present invention relates to a method and composition for optimized intracellular delivery of nucleic acids, in particular mRNA. In addition to mRNA, the composition, in particular a nanoparticle, may include a glycolipid antigen. Combinations with checkpoint inhibitors are also provided. The method and composition of the invention targets antigen presenting cells and is especially useful for immunotherapy and vaccination purposes.