The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2026
Filed:
Sep. 19, 2019
Applicant:
The University of Hong Kong, Hong Kong, HK;
Inventors:
Dan Yang, Hong Kong, HK;
Chi-Wang MA, Hong Kong, HK;
Assignee:
THE UNIVERSITY OF HONG KONG, Hong Kong, HK;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/34 (2006.01); C07B 43/00 (2006.01); C07D 477/04 (2006.01); C07D 477/14 (2006.01); C07D 499/06 (2006.01); C07D 499/883 (2006.01); C12Q 1/02 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/34 (2013.01); C07B 43/00 (2013.01); C07D 477/04 (2013.01); C07D 477/14 (2013.01); C07D 499/06 (2013.01); C07D 499/883 (2013.01); C12Q 1/025 (2013.01); G01N 21/6428 (2013.01); C12Q 2334/10 (2013.01); G01N 2021/6432 (2013.01); G01N 2333/986 (2013.01);
Abstract
Beta-lactam compounds to detect carbapenemases or microbial carbapenem resistance are disclosed. The compounds contain a chemical probe. Upon hydrolysis by carbapenemases, the compounds undergo intramolecular rearrangement and release the chemical probe. Detection of the released chemical probe indicates the presence of carbapenemases and the presence of microbial carbapenem resistance.