The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 12, 2026

Filed:

May. 04, 2021
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Austin G. Smith, Cary, NC (US);

Michael T. Corbett, Agoura Hills, CA (US);

Neil Fred Langille, Sudbury, MA (US);

Kyle D. Baucom, Ventura, CA (US);

Peter K. Dornan, Stoneham, MA (US);

Gabrielle St- Pierre, Thousand Oaks, CA (US);

Philipp C. Roosen, Thousand Oaks, CA (US);

Sheng Cui, Lexington, MA (US);

Roberto Profeta, Rovigo, IT;

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 67/62 (2006.01); C07D 249/18 (2006.01); C07D 513/08 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07C 67/62 (2013.01); C07D 249/18 (2013.01); C07D 513/08 (2013.01); C07D 519/00 (2013.01); C07B 2200/13 (2013.01);
Abstract

Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein Rand OPGare described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.


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