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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12616706 B1

PDFFull Text
Date of Patent:
May. 05, 2026

Filed:

Mar. 06, 2020

Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations

Applicant:

Arbormentis Llc, Miami Beach, FL (US);

Inventors:

Paolo L. Manfredi, Miami Beach, FL (US);

Charles E. Inturrisi, New York, NY (US);

Sara De Martin, Vigonza, IT;

Andrea Mattarei, Perarolo di Vigonza, IT;

Maurizio Rolando, Genoa, IT;

Giovanni Giordano, Genoa, IT;

Claudia Lodovichi, Padua, IT;

Paola Brun, Padua, IT;

Marco Pappagallo, New York, NY (US);

Franco Folli, Milan, IT;

Andrea Alimonti, Bellinzona, CH;

Jacopo Sgrignani, Almenno San Salvatore, IT;

Andrea Cavalli, Zurich, CH;

Assignee:

Arbormentis LLC, Miami Beach, FL (US);

Attorney:

Wood Herron & Evans LLP

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 209/16 (2006.01); A61K 31/13 (2006.01); A61K 31/135 (2006.01); A61K 31/137 (2006.01); A61K 31/4045 (2006.01); A61K 31/485 (2006.01); A61K 31/55 (2006.01); A61K 31/675 (2006.01); A61K 33/00 (2006.01); A61K 33/06 (2006.01); A61K 33/30 (2006.01); A61P 1/16 (2006.01); A61P 3/10 (2006.01); A61P 25/28 (2006.01); A61P 27/10 (2006.01); C07C 217/60 (2006.01); C07D 471/06 (2006.01); C07D 471/22 (2006.01); C07F 9/572 (2006.01);
U.S. Cl.
CPC ...
A61K 31/675 (2013.01); A61K 31/13 (2013.01); A61K 31/135 (2013.01); A61K 31/137 (2013.01); A61K 31/4045 (2013.01); A61K 31/485 (2013.01); A61K 31/55 (2013.01); A61K 33/00 (2013.01); A61K 33/06 (2013.01); A61K 33/30 (2013.01); A61P 1/16 (2018.01); A61P 3/10 (2018.01); A61P 25/28 (2018.01); A61P 27/10 (2018.01); C07C 217/60 (2013.01); C07D 209/16 (2013.01); C07D 471/06 (2013.01); C07D 471/22 (2013.01); C07F 9/5728 (2013.01);
Abstract

Compositions and methods of use comprising serotonin (5-HT) receptor agonists and NMDAR modulating substances, including especially certain substances classified as 5-HT2A agonists presently disclosed to exert NMDAR modulating effects, administered as modulators of neural plasticity, at non-psychedelic/psychotomimetic dosages, posology and formulations, for treatment of diseases and conditions and for improving functions (neuroplastogens).

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