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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12584115 B1

PDFFull Text
Date of Patent:
Mar. 24, 2026

Filed:

Nov. 02, 2022

Models and methods to establish perfusable, compartmentalized, lymphoid tissue models in three-dimensional in vitro culture

Applicant:

Advanced Solutions Life Sciences, Llc, Louisville, KY (US);

Inventors:

James B. Hoying, Manchester, NH (US);

Hannah A. Strobel, Manchester, NH (US);

Sarah Moss, Manchester, NH (US);

Assignee:

ADVANCED SOLUTIONS LIFE SCIENCES, LLC, Louisville, KY (US);

Attorney:

DINSMORE & SHOHL LLP

Primary Examiner:

Michael L Hobbs

Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12M 1/00 (2006.01); C12M 3/06 (2006.01); C12N 5/0781 (2010.01); C12N 5/0783 (2010.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0697 (2013.01); C12M 23/16 (2013.01); C12M 29/10 (2013.01); C12N 5/0635 (2013.01); C12N 5/0636 (2013.01); C12P 21/00 (2013.01); C12N 2513/00 (2013.01); C12N 2533/90 (2013.01);
Abstract

A three-dimensional (3D) lymphoid tissue model is provided, the model including a cellularized stromal compartment and a plurality of cellularized compartments including lymphocytes disposed within the stromal compartment; and a controlled fluid perfusion system configured to perfuse the model with a perfusion fluid. Methods of fabricating a 3D lymphoid tissue model and producing antibodies with the 3D lymphoid tissue model are also provided.

Find Patent Forward Citations

Hoying, James. (2026). Models and methods to establish perfusable, compartmentalized, lymphoid tissue models in three-dimensional in vitro culture (U.S. Patent No. 12584115). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12584115

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