The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2026
Filed:
Sep. 04, 2019
Applicants:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Aaron Whiteley, Brookline, MA (US);
Philip J. Kranzusch, Brighton, MA (US);
John Mekalanos, Newton, MA (US);
James Eaglesham, Boston, MA (US);
Assignees:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12N 1/20 (2006.01); C12N 11/06 (2006.01); C12N 15/10 (2006.01); C12N 15/113 (2010.01); C12N 15/70 (2006.01); C12N 15/85 (2006.01); G01N 33/50 (2006.01); G01N 33/573 (2006.01); G16B 15/30 (2019.01);
U.S. Cl.
CPC ...
C12N 9/1241 (2013.01); C12N 1/20 (2013.01); C12N 11/06 (2013.01); C12N 15/10 (2013.01); C12N 15/1137 (2013.01); C12N 15/70 (2013.01); C12N 15/8509 (2013.01); G01N 33/5023 (2013.01); G01N 33/573 (2013.01); G16B 15/30 (2019.02); C12N 2015/8527 (2013.01); C12N 2310/14 (2013.01); G01N 2333/91245 (2013.01);
Abstract
The present invention is based, in part, on the discovery and characterization of the CD-NTase family of proteins, as well as compositions comprising CD-NTases, methods of producing nucleotide-based second messengers using such polypeptides, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides.