The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2025

Filed:

Mar. 30, 2022
Applicant:

Remegen Co., Ltd., Yantai, CN;

Inventors:

Xuejing Yao, Yantai, CN;

Fangfang Sun, Yantai, CN;

Wenlong Sun, Yantai, CN;

Guiping Qi, Yantai, CN;

Assignee:

REMEGEN CO., LTD., Yantai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 30/72 (2006.01); B01D 15/10 (2006.01); G01N 30/02 (2006.01); G01N 30/06 (2006.01);
U.S. Cl.
CPC ...
G01N 30/7233 (2013.01); B01D 15/10 (2013.01); G01N 30/06 (2013.01); G01N 2030/027 (2013.01);
Abstract

The present disclosure relates to a method for detecting DTPA content in ADC by LC-MS/MS. The samples are derivatized with Feunder a weak alkaline derivatization condition, and a weak alkaline mobile phase is used, without need for addition of ion-pair reagents. This method has the characteristics of high efficiency, high stability and strong durability, and can well make up for the defects of few DTPA detection methods and complicated operations in the prior art.


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