The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2025
Filed:
Nov. 01, 2022
Syntis Bio, Inc., Boston, MA (US);
Jonathan Benjamin Asfaha, Oakland, CA (US);
Subhamoy Das, Menlo Park, CA (US);
Faye Loan Du, San Jose, CA (US);
Stephan Jenne, Foster City, CA (US);
Nikki D. Kruse, San Carlos, CA (US);
Joyce Liu, Fremont, CA (US);
Kerryn Mccluskie, Pacifica, CA (US);
Roasa Mehmood, Fremont, CA (US);
Adam P. Silverman, San Carlos, CA (US);
Kristen Jean Vallieu, Las Vegas, NV (US);
Syntis Bio, Inc., Boston, MA (US);
Abstract
The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase polypeptides. In some embodiments, the engineered leucine decarboxylase polypeptides display enhanced catalytic activity, as well as reduced sensitivity to proteolysis, and/or increased tolerance to low pH environments. In some embodiments, the engineered leucine decarboxylase polypeptides are optimized to provide improved storage stability. The present invention also provides methods for the use of the compositions comprising the engineered leucine decarboxylase polypeptides for therapeutic and industrial purposes.