The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2025
Filed:
May. 12, 2025
Applicant:
C4 Therapeutics, Inc., Watertown, MA (US);
Inventors:
Christopher G. Nasveschuk, Stoneham, MA (US);
Martin Duplessis, Somerville, MA (US);
Jae Young Ahn, Somerville, MA (US);
Alexander W. Hird, Belmont, MA (US);
Ryan E. Michael, Erie, CO (US);
Kiel Lazarski, Boston, MA (US);
Yanke Liang, Belmont, MA (US);
Georg Jaeschke, Basel, CH;
Antonio Ricci, Biel-Benken, CH;
Annick Goergler, Colmar, FR;
Daniel Rueher, Raedersdorf, FR;
Assignee:
C4 THERAPEUTICS, INC., Watertown, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01); A61K 9/00 (2006.01); A61K 9/02 (2006.01); A61K 9/08 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/38 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 9/009 (2013.01); A61K 9/02 (2013.01); A61K 9/08 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/4825 (2013.01); A61K 9/485 (2013.01); A61K 9/4858 (2013.01); A61K 9/4866 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/38 (2013.01); C07D 487/04 (2013.01);
Abstract
The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.