The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 02, 2025

Filed:

Dec. 13, 2024
Applicant:

C4 Therapeutics, Inc., Watertown, MA (US);

Inventors:

Christopher G. Nasveschuk, Stoneham, MA (US);

Katrina L. Jackson, Weston, MA (US);

Yanke Liang, Belmont, MA (US);

Martin Duplessis, Somerville, MA (US);

Mark E. Fitzgerald, Newton, MA (US);

Cosimo Dolente, Allschwil, CH;

David Stephen Hewings, Basel, CH;

Daniel Hunziker, Möhlin, CH;

Daniela Krummenacher, Zurich, CH;

Piergiorgio Francesco Tommaso Pettazzoni, Regensdorf, CH;

Juergen Wichmann, Steinen, DE;

Assignee:

C4 THERAPEUTICS, INC., Watertown, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/72 (2006.01); A61P 35/00 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 471/10 (2006.01); C07D 491/107 (2006.01); C07D 495/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61P 35/00 (2018.01); C07D 405/14 (2013.01); C07D 471/10 (2013.01); C07D 491/107 (2013.01); C07D 495/10 (2013.01);
Abstract

The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.


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