The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 18, 2025

Filed:

Feb. 02, 2020
Applicant:

Institute of Biophysics, Chinese Academy of Sciences, Beijing, CN;

Inventors:

Lusheng Gu, Beijing, CN;

Wei Ji, Beijing, CN;

Tao Xu, Beijing, CN;

Yanhui Fu, Beijing, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); G02B 21/00 (2006.01); G02B 21/04 (2006.01); G02B 26/10 (2006.01); G02B 27/14 (2006.01); G02B 27/28 (2006.01); G02F 1/11 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6402 (2013.01); G01N 21/6458 (2013.01); G02B 21/0032 (2013.01); G02B 21/0048 (2013.01); G02B 21/0076 (2013.01); G02B 21/008 (2013.01); G02B 21/04 (2013.01); G02B 26/101 (2013.01); G02B 27/141 (2013.01); G02B 27/283 (2013.01); G02B 27/286 (2013.01); G02F 1/11 (2013.01);
Abstract

Disclosed are a device and method for measuring fluorescence signal in multi-illumination mode and use of the method. An excitation light is modulated on an illumination excitation light path, to generates excitation illumination patterns at different phases on a sample after passing through an objective lens; a high-speed switching device is arranged on a fluorescence collection light path to switch the position of a fluorescence image of the sample on a target plane of a photoelectric sensor, and a plurality of sub-images can be simultaneously obtained after one exposure through synchronous operation of multi-illumination excitation light paths and fluorescence imaging light paths, which correspond to fluorescence signals in a plurality of illumination modes.


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