The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2025
Filed:
Sep. 23, 2020
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Nilesh Zaware, Jamaica, NY (US);
Ming-Ming Zhou, Old Greenwich, CT (US);
Chunyan Ren, Malden, MA (US);
Claudia Kim, New York, NY (US);
Sudeh Izadmehr, New York, NY (US);
Matthew Galsky, New York, NY (US);
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 235/30 (2006.01); A61P 35/00 (2006.01); C07D 209/08 (2006.01); C07D 403/06 (2006.01);
U.S. Cl.
CPC ...
C07D 235/30 (2013.01); A61P 35/00 (2018.01); C07D 209/08 (2013.01); C07D 403/06 (2013.01);
Abstract
A genus of bicyclic inhibitors of CBX chromodomains is disclosed. The compounds are of the following genus: in which A, E, and G represent carbon or nitrogen such that the compounds are indoles or benzimidazoles. A particular subgenus of 1,3-disubstituted-1,3-dihydro-2H-benzo[d]imidazol-2-imines is of the general formula: The compounds inhibit CBX proteins.