The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Dec. 19, 2024
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Michelle Ngai, Fitchburg, WI (US);
Mark Majewski, Rockton, IL (US);
Zhi-Ming Ding, Waunakee, WI (US);
Agnieszka Glebocka, Madison, WI (US);
Tao Pei, Middleton, WI (US);
James C. Hamilton, Sierra Madre, CA (US);
Grigoriy Shekhtman, Los Angeles, CA (US);
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Abstract
Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of an Activin Receptor-Like Kinase 7 (ALK7) gene. The ALK7 RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an ALK7 gene. Pharmaceutical compositions that include one or more ALK7 RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described ALK7 RNAi agents to adipose tissue, in vivo, provides for inhibition of ALK7 gene expression and a reduction in ALK7 activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including obesity, diabetes, or insulin resistance.