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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12441740 B1

PDFFull Text
Date of Patent:
Oct. 14, 2025

Filed:

Dec. 09, 2024

N/o-linked degrons and degronimers for protein degradation

Applicant:

C4 Therapeutics, Inc., Watertown, MA (US);

Inventors:

Andrew J. Phillips, Littleton, CO (US);

Christopher G. Nasveschuk, Stoneham, MA (US);

James A. Henderson, Weston, MA (US);

Yanke Liang, Belmont, MA (US);

Minsheng He, Andover, MA (US);

Martin Duplessis, Somerville, MA (US);

Chi-Li Chen, Newton, MA (US);

Assignee:

C4 THERAPEUTICS, INC., Watertown, MA (US);

Attorney:

Knowles Intellectual Property Strategies, LLC

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07D 495/14 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61P 35/00 (2006.01); C07D 207/456 (2006.01); C07D 211/88 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); G07F 17/32 (2006.01);
U.S. Cl.
CPC ...
C07D 495/14 (2013.01); C07D 207/456 (2013.01); C07D 211/88 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); G07F 17/3211 (2013.01); G07F 17/3225 (2013.01); G07F 17/3244 (2013.01); G07F 17/3246 (2013.01); G07F 17/3272 (2013.01); G07F 17/3288 (2013.01);
Abstract

This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

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