The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2025
Filed:
Apr. 28, 2021
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Neil Fred Langille, Sudbury, MA (US);
Jason S. Tedrow, Salem, MA (US);
Jonathan Vinh-Phu Truong, Thousand Oaks, CA (US);
Robert Ronald Milburn, Belmont, CA (US);
Alessandro Arena, Vicenza, IT;
Assignees:
AMGEN INC., Thousand Oaks, CA (US);
F.I.S.—FABBRICA ITALIANA SINTETICI SPA, Vicenza, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 303/36 (2006.01); C07C 29/62 (2006.01); C07C 67/08 (2006.01); C07C 303/28 (2006.01); C07D 213/70 (2006.01); C07D 213/71 (2006.01); C07D 301/24 (2006.01); C07D 513/06 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07C 303/36 (2013.01); C07C 29/62 (2013.01); C07C 67/08 (2013.01); C07C 303/28 (2013.01); C07D 213/70 (2013.01); C07D 213/71 (2013.01); C07D 301/24 (2013.01); C07D 513/06 (2013.01); C07D 519/00 (2013.01); C07B 2200/13 (2013.01);
Abstract
Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.