The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2025
Filed:
Apr. 17, 2024
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Patrick Leonard Ahl, West Point, PA (US);
Akhilesh Bhambhani, Doylestown, PA (US);
Christopher Jon Farrell, Wayne, PA (US);
Patrick Mchugh, Pipersville, PA (US);
Morrisa C. Jones, Upper Darby, PA (US);
Daniel D. Roth, Coopersburg, PA (US);
Jessica R. Sinacola, Collegeville, PA (US);
Justin Stanbro, Sellersville, PA (US);
Matthew P. Watson, Ottsville, PA (US);
Emily Wen, Harleysville, PA (US);
Michael A. Winters, Doylestown, PA (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.