The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 16, 2025

Filed:

May. 14, 2019
Applicant:

Harpoon Therapeutics, Inc., South San Francisco, CA (US);

Inventors:

Shuoyen Jack Lin, San Bruno, CA (US);

Richard J. Austin, San Francisco, CA (US);

Bryan D. Lemon, Mountain View, CA (US);

Kathryn Kwant, San Bruno, CA (US);

Sony S. Rocha, San Francisco, CA (US);

Holger Wesche, San Francisco, CA (US);

Assignee:

Harpoon Therapeutics, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/00 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); C07K 16/2809 (2013.01); C07K 16/2878 (2013.01); C07K 16/3069 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/60 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01);
Abstract

Disclosed herein are binding moieties that comprise non-CDR loops for masking the binding of a binding molecule to its target and CDRs for binding bulk serum proteins. Conditionally active target binding proteins that contain the binding moieties are also provided. Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of using such formulations are further provided.


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