The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2025
Filed:
Jan. 04, 2022
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Morassa Mohseni Middleton, San Diego, CA (US);
Mark C. Wallen, San Diego, CA (US);
Pinar Iyidogan, San Diego, CA (US);
Michael James Schmidt, San Diego, CA (US);
Brittany A. Rohrman, La Jolla, CA (US);
Ying Lin Liu, San Diego, CA (US);
Fabian Block, San Diego, CA (US);
Arnold Oliphant, Morgan Hill, CA (US);
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Abstract
Methods, compositions, kits and apparatuses that include a fluid, the fluid containing a ternary complex and Li, wherein the ternary complex includes a primed template nucleic acid, a polymerase, and a nucleotide cognate for the next correct base for the primed template nucleic acid molecule. As an alternative or addition to Li, the fluid can contain betaine or a metal ion that inhibits polymerase catalysis such as Ca. In addition to Li, the fluid can contain polyethylenimine (PEI) with or without betaine.