The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2025
Filed:
Feb. 03, 2023
Applicant:
Kalivir Immunotherapeutics, Inc., Pittsburgh, PA (US);
Inventors:
Stephen Howard Thorne, Pittsburgh, PA (US);
Mingrui Zhang, Pittsburgh, PA (US);
Daniel J. Byrd, Pittsburgh, PA (US);
Assignee:
KaliVir Immunotherapeutcs, Inc., Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61P 35/00 (2006.01); C07K 14/55 (2006.01); C07K 14/575 (2006.01); C07K 14/715 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61P 35/00 (2018.01); C07K 14/55 (2013.01); C07K 14/5759 (2013.01); C07K 14/7158 (2013.01); C12N 15/86 (2013.01); C12N 2710/24132 (2013.01); C12N 2710/24143 (2013.01); C12N 2710/24171 (2013.01);
Abstract
The disclosure relates to modified oncolytic viruses. The modified oncolytic viruses of the disclosure comprise modification in the viral genome encoding exogenous nucleic acids to enhance the oncolytic immunotherapy by remodeling the tumor microenvironment and with enhanced systemic delivery. The disclosure further relates to compositions comprising the modified oncolytic viruses, kits containing the same, and methods of using the oncolytic viruses.