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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12403165 B1

PDFFull Text
Date of Patent:
Sep. 02, 2025

Filed:

Feb. 03, 2023

Oncolytic immunotherapy by tumor micro-environment remodeling

Applicant:

Kalivir Immunotherapeutics, Inc., Pittsburgh, PA (US);

Inventors:

Stephen Howard Thorne, Pittsburgh, PA (US);

Mingrui Zhang, Pittsburgh, PA (US);

Daniel J. Byrd, Pittsburgh, PA (US);

Assignee:

KaliVir Immunotherapeutcs, Inc., Pittsburgh, PA (US);

Attorney:

Greenberg Traurig, LLP

Primary Examiner:

Christopher M Babic

Assistant Examiner:

Kimberly A Aron

Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61P 35/00 (2006.01); C07K 14/55 (2006.01); C07K 14/575 (2006.01); C07K 14/715 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61P 35/00 (2018.01); C07K 14/55 (2013.01); C07K 14/5759 (2013.01); C07K 14/7158 (2013.01); C12N 15/86 (2013.01); C12N 2710/24132 (2013.01); C12N 2710/24143 (2013.01); C12N 2710/24171 (2013.01);
Abstract

The disclosure relates to modified oncolytic viruses. The modified oncolytic viruses of the disclosure comprise modification in the viral genome encoding exogenous nucleic acids to enhance the oncolytic immunotherapy by remodeling the tumor microenvironment and with enhanced systemic delivery. The disclosure further relates to compositions comprising the modified oncolytic viruses, kits containing the same, and methods of using the oncolytic viruses.

Find Patent Forward Citations

Thorne, Stephen. (2025). Oncolytic immunotherapy by tumor micro-environment remodeling (U.S. Patent No. 12403165). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12403165

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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