The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Mar. 24, 2023
Shaanxi University of Science and Technology, Xi'an, CN;
Chenguan Liang, Xi'an, CN;
Kairui Kang, Xi'an, CN;
Changhua Ke, Xi'an, CN;
Yanzi Wang, Xi'an, CN;
Yuting Liu, Xi'an, CN;
Xiuding Yang, Xi'an, CN;
Ying Zhou, Xi'an, CN;
Jiaxuan Li, Xi'an, CN;
SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY, Shaanxi, CN;
Abstract
The present invention discloses a pleuromutilin derivative containing thiazole-pyridine benzyl quaternary ammonium salt side chain and a preparation method and use thereof and belongs to the field of medicinal chemistry. A pleuromutilin derivative with thiazole-pyridine benzyl quaternary ammonium salt side chain is successfully prepared by structural reconstruction of pleuromutilin and then structural modification with a quaternary ammonium salt compound. This compound synthesis method has the advantages of easily available raw materials, simple operation and high product yield, and is suitable for industrial production. The results of in vitro pharmacological experiments show that the pleuromutilin derivative of the present invention have good antibacterial and anti-mycoplasma activities, as well as good solubility, and these results show that the pleuromutilin derivative is of great value in the development of an anti-pathogenic microorganism drug.