The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Jan. 10, 2025
Yikang Biotech (Suzhou) Co., Ltd., Jiangsu, CN;
Lei Chen, Suzhou, CN;
Yujiao Song, Suzhou, CN;
Min Dai, Suzhou, CN;
Xin Xie, Suzhou, CN;
Shibi Zhao, Suzhou, CN;
Jiahao Xu, Suzhou, CN;
Yujuan Hua, Suzhou, CN;
Chao Wu, Suzhou, CN;
Sufang Gu, Suzhou, CN;
Tao Fang, Suzhou, CN;
Li Chen, Suzhou, CN;
Jiadi Huang, Suzhou, CN;
Xiaoya Ding, Suzhou, CN;
Mingze Shi, Suzhou, CN;
Peizhe Li, Suzhou, CN;
Jiaxin Lei, Suzhou, CN;
Guangsha Zhang, Suzhou, CN;
Meng Zhang, Suzhou, CN;
Wendie Wang, Suzhou, CN;
Ruihong Jiang, Suzhou, CN;
Songming He, Suzhou, CN;
Derong Wang, Suzhou, CN;
Tengsen Gao, Suzhou, CN;
Eric Chen, Suzhou, CN;
Jianguo Yin, Suzhou, CN;
YIKANG BIOTECH (SUZHOU) CO., LTD., Suzhou, CN;
Abstract
The present disclosure relates to the field of biomedicine, and in particular, to an improved mutant of a respiratory syncytial virus (RSV) fusion (F) protein and uses thereof. The mutant can form a trimeric structure without introducing a heterologous trimerization domain. Meanwhile, through mutation designs such as releasing internal electrostatic repulsion, deleting the furin cleavage site, truncating the C-terminal domain, and introducing interchain disulfide bonds, the protein is stabilized in the pre-fusion conformation and exhibits enhanced stability. The mutant in the present disclosure is highly immunogenic when used as a vaccine or a vaccine component and can induce the production of a high level of neutralizing antibodies in the immunized animal, which can be used in the preparation of a vaccine for the prevention or treatment of RSV infection, and can also be used as a reagent for the detection of RSV.