The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Nov. 01, 2023
Jiangnan University, Jiangsu, CN;
Inner Mongolia Mengniu Dairy (Group) Company Limited, Inner Mongolia, CN;
Long Liu, Wuxi, CN;
Jian Chen, Wuxi, CN;
Xueqin Lv, Wuxi, CN;
Wenyang Wu, Wuxi, CN;
Guocheng Du, Wuxi, CN;
Jianghua Li, Wuxi, CN;
Guolin Zhou, Wuxi, CN;
Yanfeng Liu, Wuxi, CN;
Chenyang Zhang, Wuxi, CN;
JIANGNAN UNIVERSITY, Jiangsu, CN;
INNER MONGOLIA MENGNIU DAIRY (GROUP) COMPANY LIMITED, Inner Mongolia, CN;
Abstract
The invention provides astrain for producing a human milk lipid substitute. By integrating a heterologous lysophosphatidic acid acyltransferase intoand knocking out its own natural lysophosphatidic acid acyltransferase, the content of palmitic acid (C16:0) at Sn-2 position of triacylglycerol produced byis increased, to synthesize a human milk lipid substitute. On this basis, a metabolic pathway related gene is knocked out, to further increase the content of human milk lipid substitute in the product. In the present invention, a human milk lipid substitute is de novo synthesized byfor the first time, in which the total fatty acid is 15% or more, and the relative content of C16:0 at Sn-2 position reaches about 60%.