The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Apr. 15, 2022
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Mark Keating, Weston, MA (US);
James D. McIninch, Burlington, MA (US);
Elane Fishilevich, Rochester, MA (US);
Kristina Yucius, Burlington, MA (US);
Sarah Solomon, Cambridge, MA (US);
Mark K. Schlegel, Boston, MA (US);
Adam Castoreno, Framingham, MA (US);
Charalambos Kaittanis, Cambridge, MA (US);
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the complement component C3 gene (C3). The invention also relates to methods of using such RNAi agents to inhibit expression of a C3 gene and to methods of preventing and treating a C3-associated disorder, e.g., cold agglutinin disease (CAD), warm autoimmune hemolytic anemia, and paroxysmal nocturnal hemoglobinuria (PNH), lupis nephritis (LN), bullous pemphigoid, Pemphigus, e.g., Pemphigus vulgaris (PV) and Pemphigus foliaceus (PF), and C3 glomerulopathy.