The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
May. 15, 2023
Shanxi Jinbo Bio-pharmaceutical Co., Ltd., Shanxi, CN;
Fudan University, Shanghai, CN;
Lu Lu, Shanghai, CN;
Shibo Jiang, Shanghai, CN;
Zezhong Liu, Shanghai, CN;
Jie Zhou, Shanghai, CN;
Qian Wang, Shanghai, CN;
Xia Yang, Shanxi, CN;
Zhenrui He, Shanxi, CN;
SHANXI JINBO BIO-PHARMACEUTICAL CO., LTD., Shanxi, CN;
FUDAN UNIVERSITY, Shanghai, CN;
Abstract
Provided are a fusion protein and use thereof. Provided is a fusion protein, comprising a trimerization block and an immunogenic block which are connected by a linker, wherein the trimerization block comprises one or more of repeat units set forth in SEQ ID NO. 1; the immunogenic block is an immunogenic protein of a pathogen, for example, being selected from a coronavirus RBD block, an HIV membrane protein or an influenza virus hemagglutinin protein, and immunogenic fragments thereof. Compared with an immunogen monomer, the trimer can generate a higher neutralizing antibody level, does not induce a strong antibody against the trimerization block in a human body, and can promote the immune response of the organism to be focused on the immunogenic block.