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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12350264 B1

PDFFull Text
Date of Patent:
Jul. 08, 2025

Filed:

Dec. 12, 2023

Compositions and methods for treating, preventing or reversing age-associated inflammation and disorder

Applicant:

Brown University, Providence, RI (US);

Inventors:

John M. Sedivy, Barrington, RI (US);

Gerwald Jogl, Pawtucket, RI (US);

Alexandra D'Ordine, Lakeville, MA (US);

Assignee:

Brown University, Providence, RI (US);

Attorney:

Adler Pollock & Sheehan P.C.

Primary Examiner:

Leslie A Royds Draper

Int. Cl.
CPC ...
A61K 31/554 (2006.01); A61K 31/136 (2006.01); A61K 31/145 (2006.01); A61K 31/166 (2006.01); A61K 31/167 (2006.01); A61K 31/17 (2006.01); A61K 31/19 (2006.01); A61K 31/192 (2006.01); A61K 31/194 (2006.01); A61K 31/195 (2006.01); A61K 31/196 (2006.01); A61K 31/366 (2006.01); A61K 31/381 (2006.01); A61K 31/4015 (2006.01); A61K 31/4035 (2006.01); A61K 31/4192 (2006.01); A61K 31/423 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01); A61K 31/445 (2006.01); A61K 31/4704 (2006.01); A61K 31/4741 (2006.01); A61K 31/50 (2006.01); A61K 31/501 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4741 (2013.01); A61K 31/136 (2013.01); A61K 31/145 (2013.01); A61K 31/166 (2013.01); A61K 31/167 (2013.01); A61K 31/17 (2013.01); A61K 31/19 (2013.01); A61K 31/192 (2013.01); A61K 31/194 (2013.01); A61K 31/195 (2013.01); A61K 31/196 (2013.01); A61K 31/366 (2013.01); A61K 31/381 (2013.01); A61K 31/4015 (2013.01); A61K 31/4035 (2013.01); A61K 31/4192 (2013.01); A61K 31/423 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); A61K 31/445 (2013.01); A61K 31/4704 (2013.01); A61K 31/50 (2013.01); A61K 31/501 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 31/554 (2013.01); A61P 29/00 (2018.01);
Abstract

Disclosed are methods for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one long interspersed nuclear element 1 (LINE-1, L1) endonuclease inhibitor (L1 EN inhibitor), either alone or in combination with at least one additional therapeutic agent. Effectiveness of the methods can be measured via biomarkers and/or by a decrease in symptoms compared to those symptoms before administration of the L1 EN inhibitor. Specific chemical structures of the L1 EN inhibitors are identified and shown herein.

Find Patent Forward Citations

Sedivy, John. (2025). Compositions and methods for treating, preventing or reversing age-associated inflammation and disorder (U.S. Patent No. 12350264). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12350264

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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