The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 24, 2025

Filed:

Apr. 27, 2020
Applicants:

Health Research, Inc., Buffalo, NY (US);

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

James L. Mohler, Buffalo, NY (US);

Michael V. Fiandalo, Buffalo, NY (US);

David Watt, Lexington, KY (US);

Vitaliy Sviripa, Frederick, MD (US);

Assignees:

Health Research, Inc., Buffalo, NY (US);

University of Kentucky Research Foundation, Lexington, KY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/585 (2006.01); A61K 31/167 (2006.01); A61K 31/277 (2006.01); A61K 31/4155 (2006.01); A61K 31/4166 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/58 (2006.01); A61K 49/00 (2006.01); C07J 43/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/585 (2013.01); A61K 31/167 (2013.01); A61K 31/277 (2013.01); A61K 31/4155 (2013.01); A61K 31/4166 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/58 (2013.01); A61K 49/0002 (2013.01); C07J 43/003 (2013.01); C07J 43/006 (2013.01);
Abstract

Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.


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