The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 17, 2025

Filed:

Jan. 03, 2021
Applicant:

Yeda Research and Development Co. Ltd., Rehovot, IL;

Inventors:

David Margulies, Rehovot, IL;

Leila Motiei, Rehovot, IL;

Pragati Prasad, Rehovot, IL;

Tom Granot, Rehovot, IL;

Ohad Suss, Rehovot, IL;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/58 (2006.01); C07C 227/18 (2006.01); G01N 21/64 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/582 (2013.01); G01N 21/6428 (2013.01); G01N 21/6458 (2013.01); G01N 33/5008 (2013.01); G01N 33/6803 (2013.01); G01N 2021/6439 (2013.01);
Abstract

This invention is directed to a turn-on fluorescent probe, wherein said probe comprises a quinoline based cyanine dye derivative (QBC) and a specific protein binder covalently attached thereto directly or via a linker. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further describes methods for using these turn-on probes and compounds for detecting and labelling a wide range of proteins in their native environment.


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