The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2025
Filed:
Jan. 30, 2023
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);
Technion Research & Development Foundation Ltd., Haifa, IL;
Yan Li, La Jolla, CA (US);
Scott Peterson, La Jolla, CA (US);
Linda Bradley, La Jolla, CA (US);
Roberto Tinoco, La Jolla, CA (US);
Ze'ev Ronai, San Diego, CA (US);
Shiri Ashkenazi, Haifa, IL;
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);
Technion Research & Development Foundation Ltd., Haifa, IL;
Abstract
The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.