Colchicine hydrogel microneedle and preparation method thereof

Abstract

A preparation method of a colchicine (COL) hydrogel microneedle (MN) is provided, including the following steps: dissolving an acrylamide (AM), N,N'-bis(acryloyl)cysteamine (BACA), and Irgacure 2959 in ultrapure water to obtain a clear gel solution; pouring the clear gel solution into a polydimethylsiloxane (PDMS) mold, conducting low-speed centrifugation, and conducting an ultrasonic treatment to eliminate air bubbles; irradiating the PDMS mold under ultraviolet light, and air-drying in an oven to obtain a hydrogel MN; and adding a COL solution to the hydrogel MN, allowing swelling, air-drying, and demolding. The present disclosure overcomes the shortcoming that cross-linking points are unevenly distributed in the ordinary hydrogel MNs. The hydrogel MN prepared by the present disclosure has a complete needle shape, a neat matrix arrangement, cross-linking points evenly distributed in a network, and excellent mechanical toughness and a superior swelling capacity.