The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Aug. 10, 2017
Amgen Inc., Thousand Oaks, CA (US);
Amgen Research (Munich) Gmbh, Munich, DE;
Shouhua Xiao, Foster City, CA (US);
Zheng Pan, Fremont, CA (US);
Dineli Wickramasinghe, San Francisco, CA (US);
Peter Kufer, Munich, DE;
Patrick Hoffmann, Munich, DE;
Tobias Raum, Munich, DE;
Ralf Lutterbüse, Munich, DE;
Elisabeth Nahrwold, Munich, DE;
Claudia Blumel, Munich, DE;
AMGEN INC., Thousand Oaks, CA (US);
AMGEN RESEARCH (MUNICH) GMBH, Munich, DE;
Abstract
A bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. A nucleic acid comprising a polynucleotide encoding the antibody construct, a vector comprising the nucleic acid comprising the polynucleotide and a host cell transformed or transfected with the nucleic acid comprising the polynucleotide or vector. A process for the production of the antibody construct, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.