The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2025
Filed:
Jun. 22, 2023
Applicant:
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Inventors:
Julie M. Skinner, Phoenixville, PA (US);
Patrick McHugh, Pipersville, PA (US);
Assignee:
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/09 (2006.01); A61K 39/00 (2006.01); A61K 39/116 (2006.01); A61K 47/64 (2017.01); A61P 31/04 (2006.01);
U.S. Cl.
CPC ...
A61K 39/092 (2013.01); A61K 39/116 (2013.01); A61K 47/646 (2017.08); A61P 31/04 (2018.01); A61K 2039/6037 (2013.01);
Abstract
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides frombacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.