The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2025
Filed:
Aug. 07, 2019
Applicant:
Max-delbrück-centrum Für Molekulare Medizin IN Der Helmholtz-gemeinschaft, Berlin, DE;
Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2005.12); C07K 14/47 (2005.12); G01N 33/542 (2005.12);
U.S. Cl.
CPC ...
G01N 33/6896 (2012.12); C07K 14/4711 (2012.12); G01N 33/542 (2012.12); G01N 2500/20 (2012.12); G01N 2800/2835 (2012.12); G01N 2800/50 (2012.12);
Abstract
The present invention relates to a method for the quantification of seeding (Δt) of an amyloidogenic aggregate, methods for assessing the risk for development, predicting the onset or assessing the progression of a polyQ disease, and a method for identifying compounds that inhibit mHTT seeding activity (HSA) in vitro. Further, uses of fluorophore-bearing polyQ proteins, particularly mutant N-terminal huntingtin fragments comprising exon-1 and related soluble protein constructs are provided.
Quick Actions:
Ast, Anne. (2025). Fret-based method to measure seeding activity of misfolded protein species in biological samples (U.S. Patent No. 12287344). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12287344
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile